英國牛津大學(xué)David Dupret和Charlie J. Clarke-Williams共同合作,近期取得重要工作進展。他們研究發(fā)現(xiàn)了協(xié)調(diào)抵抗記憶消失的大腦分布式網(wǎng)絡(luò)活動。相關(guān)研究成果2024年1月18日在線發(fā)表于《細胞》雜志上。
據(jù)介紹,某些記憶抗拒消失,以繼續(xù)激發(fā)適應(yīng)不良的行為。這些記憶的穩(wěn)定性可能取決于它們在多個大腦區(qū)域的神經(jīng)元群體中的廣泛分布。然而,分散的神經(jīng)元活動是如何集體組織起來以支持持續(xù)的記憶引導(dǎo)行為的,這一點尚不清楚。
研究人員同時監(jiān)測了小鼠大腦的前額葉皮層、伏隔核、杏仁核、海馬體和腹側(cè)被蓋區(qū)(VTA),從最初回憶到記憶消失后的可卡因體驗記憶更新。研究人員發(fā)現(xiàn)了一種高階的短暫β頻率(15–25 Hz)活動模式,在記憶檢索過程中,這些活動在這些網(wǎng)絡(luò)中短暫協(xié)調(diào)。來自上游VTA谷氨酸能神經(jīng)元發(fā)散通路的輸出,通過較慢的(4-Hz)振蕩來驅(qū)動這種多網(wǎng)絡(luò)β波段共激活;其閉環(huán)相位信息抑制阻止了可卡因偏向行為的更新。以這種時間結(jié)構(gòu)化的方式結(jié)合大腦分布的神經(jīng)活動,可能構(gòu)成穩(wěn)健記憶表達的組織原理。
附:英文原文
Title: Coordinating brain-distributed network activities in memory resistant to extinction
Author: Charlie J. Clarke-Williams, Vítor Lopes-dos-Santos, Laura Lefèvre, Demi Brizee, Adrien A. Causse, Roman Rothaermel, Katja Hartwich, Pavel V. Perestenko, Robert Toth, Colin G. McNamara, Andrew Sharott, David Dupret
Issue&Volume: 2024/01/18
Abstract: Certain memories resist extinction to continue invigorating maladaptive actions. The robustness of these memories could depend on their widely distributed implementation across populations of neurons in multiple brain regions. However, how dispersed neuronal activities are collectively organized to underpin a persistent memory-guided behavior remains unknown. To investigate this, we simultaneously monitored the prefrontal cortex, nucleus accumbens, amygdala, hippocampus, and ventral tegmental area (VTA) of the mouse brain from initial recall to post-extinction renewal of a memory involving cocaine experience. We uncover a higher-order pattern of short-lived beta-frequency (15–25 Hz) activities that are transiently coordinated across these networks during memory retrieval. The output of a divergent pathway from upstream VTA glutamatergic neurons, paced by a slower (4-Hz) oscillation, actuates this multi-network beta-band coactivation; its closed-loop phase-informed suppression prevents renewal of cocaine-biased behavior. Binding brain-distributed neural activities in this temporally structured manner may constitute an organizational principle of robust memory expression.
來源:科學(xué)網(wǎng)
原標題:科學(xué)家發(fā)現(xiàn)協(xié)調(diào)抵抗記憶消失的大腦分布式網(wǎng)絡(luò)活動
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