英國劍橋大學(xué)Ashley Moffett等研究人員合作發(fā)現(xiàn)，人類子宮自然殺傷細(xì)胞調(diào)節(jié)妊娠早期滋養(yǎng)層外滋養(yǎng)細(xì)胞的分化。2024年1月17日，《細(xì)胞—干細(xì)胞》雜志在線發(fā)表了這項成果。
研究人員利用滋養(yǎng)細(xì)胞器官組織和原始組織樣本，來確定了子宮自然殺傷細(xì)胞（uNK）細(xì)胞如何影響胎盤。通過使用單細(xì)胞轉(zhuǎn)錄組學(xué)定位滋養(yǎng)層細(xì)胞和uNK細(xì)胞之間潛在的相互作用軸，并在體外模擬有機體中的這些相互作用，研究人員確定了一種uNK細(xì)胞衍生的細(xì)胞因子信號，它能在侵入途徑的晚期促進滋養(yǎng)層細(xì)胞分化。
此外，它還會影響參與調(diào)節(jié)血流、營養(yǎng)、炎癥和適應(yīng)性免疫反應(yīng)的轉(zhuǎn)錄程序，以及與先兆子癇等妊娠疾病相關(guān)的基因特征。這些研究結(jié)果表明了，uNK細(xì)胞與滋養(yǎng)層細(xì)胞之間的最佳免疫學(xué)相互作用機制如何提高生殖成功率。
據(jù)悉，在人類中，滋養(yǎng)層細(xì)胞均衡地侵入子宮粘膜（蛻膜）是成功懷孕的關(guān)鍵。有證據(jù)表明，這一過程受到uNK的調(diào)控，但它們?nèi)绾斡绊懮辰Y(jié)果尚不清楚。
附：英文原文
Title: Human uterine natural killer cells regulate differentiation of extravillous trophoblast early in pregnancy
Author: Qian Li, Andrew Sharkey, Megan Sheridan, Elisa Magistrati, Anna Arutyunyan, Oisin Huhn, Carmen Sancho-Serra, Holly Anderson, Naomi McGovern, Laura Esposito, Ridma Fernando, Lucy Gardner, Roser Vento-Tormo, Margherita Yayoi Turco, Ashley Moffett
Issue&Volume: 2024-01-17
Abstract: In humans, balanced invasion of trophoblast cells into the uterine mucosa, the decidua, is critical for successful pregnancy. Evidence suggests that this process is regulated by uterine natural killer (uNK) cells, but how they influence reproductive outcomes is unclear. Here, we used our trophoblast organoids and primary tissue samples to determine how uNK cells affect placentation. By locating potential interaction axes between trophoblast and uNK cells using single-cell transcriptomics and in vitro modeling of these interactions in organoids, we identify a uNK cell-derived cytokine signal that promotes trophoblast differentiation at the late stage of the invasive pathway. Moreover, it affects transcriptional programs involved in regulating blood flow, nutrients, and inflammatory and adaptive immune responses, as well as gene signatures associated with disorders of pregnancy such as pre-eclampsia. Our findings suggest mechanisms on how optimal immunological interactions between uNK cells and trophoblast enhance reproductive success.
來源：科學(xué)網(wǎng)
原標(biāo)題：人類子宮自然殺傷細(xì)胞調(diào)節(jié)妊娠早期滋養(yǎng)層外滋養(yǎng)細(xì)胞的分化
作者：小柯
清美聯(lián)創(chuàng)秉承“四個面向”的企業(yè)哲學(xué)和價值觀——
面向人類健康
面向國防需要
面向“一帶一路”
面向人類命運共同體
北京清美聯(lián)創(chuàng)干細(xì)胞科技有限公司致力于多種干細(xì)胞臨床應(yīng)用研究，人體冷凍、核輻射防治等技術(shù)研發(fā)。
目前已擁有67種不同功能的專能細(xì)胞如神經(jīng)干細(xì)胞、胰腺干細(xì)胞、卵巢干細(xì)胞、肝臟干細(xì)胞、心肌細(xì)胞、毛囊干細(xì)胞等的制備技術(shù)。
北京清美聯(lián)創(chuàng)干細(xì)胞科技有限公司服務(wù)咨詢與技術(shù)合作電話：010-88292706。
